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SB-334867 free base
CAS No. 792173-99-0
SB-334867 free base ( SB334867A free base | SB334867 free base | SB 334867 free base )
产品货号. M15972 CAS No. 792173-99-0
第一个选择性 Orexin-1 受体拮抗剂，pKb 为 7.4。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥365 | 有现货 |
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| 5MG | ￥551 | 有现货 |
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| 10MG | ￥851 | 有现货 |
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| 25MG | ￥1790 | 有现货 |
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| 50MG | ￥3135 | 有现货 |
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| 100MG | ￥4666 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称SB-334867 free base
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述第一个选择性 Orexin-1 受体拮抗剂，pKb 为 7.4。
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产品描述The first selective Orexin-1 receptor antagonist with pKb of 7.4; displays 50-fold selectivity over OX2 (pKb 5.7), >100-fold or selectivity over 5-HT2B, 5-HT2C and approximately 50 other molecular targets, in particular GPCRs and ion channels; possesses CNS penetration, in vivo activity following ip dosing.Obesity Preclinical.
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体外实验——
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体内实验Animal Model:Male Swiss mice Dosage:20?mg/kg Administration:Intraperitoneal injectionResult:Inhibited the acquisition of morphine-induced sensitization to locomotor activity of mice.Animal Model:C57BL/6J Mice Dosage:3, 10 and 30 mg/kg Administration:Intraperitoneal injectionResult:Reduced ethanol consumption, BECs and suppressed sucrose intake in mice.
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同义词SB334867A free base | SB334867 free base | SB 334867 free base
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通路GPCR/G Protein
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靶点Orexin Receptor
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受体OX1
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研究领域Metabolic Disease
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适应症Obesity
化学信息
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CAS Number792173-99-0
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分子量319.3174
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分子式C17H13N5O2
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 49 mg/mL
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SMILESCC1=NC2=C(O1)C=C(C=C2)NC(=O)NC3=C4C(=NC=C3)C=CC=N4
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化学全称Urea, N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Smart D, et al. Br J Pharmacol. 2001 Mar;132(6):1179-82.
2. Porter RA, et al. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1907-10.
3. Rodgers RJ, et al. Eur J Neurosci. 2001 Apr;13(7):1444-52.
